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284776

Cc1cc(Nc2cc(-c3cccc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)nn(C)c2=O)nn1C
Reaction #191445
DOI: 10.1039/C8SC04228D
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(Cl)c3CO)ncc2c1
Reaction #225541
DOI: 10.1039/C8SC04228D
CC(=O)OCc1c(-c2cc(Nc3ccc(N4CC5(CN(C(=O)OC(C)(C)C)C5)C4)cn3)c(=O)n(C)n2)cccc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O
Reaction #225690
DOI: 10.1039/C8SC04228D
CC(=O)OCc1c(-c2cc(Nc3ccc(C(C)(C)N)cn3)c(=O)n(C)c2)cccc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O
Reaction #229649
DOI: 10.1039/C8SC04228D
COC1CN(Cc2ccc(Nc3cc(-c4cccc(-n5ncc6cc(C(C)(C)C)cc(F)c6c5=O)c4CO)nn(C)c3=O)nc2)C1
Reaction #244989
DOI: 10.1039/C8SC04228D
CC(=O)OCc1c(-c2cc(Nc3ccc(OC(C)(C)CN(C)C)cn3)c(=O)n(C)n2)cccc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O
Reaction #256106
DOI: 10.1039/C8SC04228D
CC(=O)OCc1c(-c2cc(Nc3cc4n(n3)CCN(C)C4)c(=O)n(C)n2)cccc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O
Reaction #265212
DOI: 10.1039/C8SC04228D
CN1CCN(Cc2ccc(Nc3cc(-c4cccc(-n5ncc6cc(C(C)(C)C)cc(F)c6c5=O)c4CO)nn(C)c3=O)nc2)CC1
Reaction #274405
DOI: 10.1039/C8SC04228D
CC(=O)OCc1c(-c2cc(Nc3ccc(N4CC5CC4CN5C)nn3)c(=O)n(C)n2)cccc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O
Reaction #393117
DOI: 10.1039/C8SC04228D
CC(=O)OCc1c(-c2cc(Nc3cc4n(n3)CCN(C3COC3)C4)c(=O)n(C)n2)cccc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O
Reaction #400704
DOI: 10.1039/C8SC04228D
CC(C)(C)c1cc(F)c2c(=O)n(-c3nccc(I)c3C=O)ncc2c1
Reaction #424459
desired product
Ausbeute 70.5%DOI: 10.6084/m9.figshare.5104873.v1
CN1CCC(c2ccc(Nc3cc(-c4ccnc(-n5ncc6cc(C(C)(C)C)cc(F)c6c5=O)c4CO)nn(C)c3=O)nc2)CC1
Reaction #424460
desired product
Ausbeute 54.2%DOI: 10.6084/m9.figshare.5104873.v1
Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(Nc2ccc(S(C)(=O)=O)cn2)c1=O
Reaction #424472
desired product
Ausbeute 58.1%DOI: 10.6084/m9.figshare.5104873.v1
CN1CCn2nc(Nc3cc(-c4ccnc(-n5ncc6cc(C(C)(C)C)ccc6c5=O)c4CO)nn(C)c3=O)cc2C1
Reaction #424486
title compound
DOI: 10.6084/m9.figshare.5104873.v1
CC(C)(C)c1cc(F)c2c(=O)n(-c3ccnc(Cl)c3C=O)ncc2c1
Reaction #424501
desired product
Ausbeute 52.0%DOI: 10.6084/m9.figshare.5104873.v1
Cn1nc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(Nc2cc3n(n2)CC[N+](C)([O-])C3)c1=O
Reaction #424508
2-(6-(2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H) -yl)-3-(hydroxymethyl)pyridin-4-yl)-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)-5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine 5-oxide
Ausbeute 30.9%DOI: 10.6084/m9.figshare.5104873.v1
CC(=O)OCc1c(-c2cc(Nc3ccc(C(=O)N4CCOCC4)cn3)c3ncnn3c2)cccc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O
Reaction #490109
acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-{8-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl}-benzyl ester
Ausbeute 95.0%DOI: 10.6084/m9.figshare.5104873.v1
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-c4cc(Nc5ccc(C(=O)N6CCOCC6)cn5)c5ncnn5c4)c3CO)ncc2c1
Reaction #490110
6-tert-butyl-8-fluoro-2-(2-hydroxymethyl-3-{8-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl}-phenyl)-2H-phthalazin-1-one
Ausbeute 23.0%DOI: 10.6084/m9.figshare.5104873.v1
CC(=O)OCc1c(-c2cc(Nc3ccc(CN4CCN(C)CC4)cn3)c3nccn3n2)cccc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O
Reaction #490116
acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-{8-[5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamino]-imidazo[1,2-b]pyridazin-6-yl}-benzyl ester
DOI: 10.6084/m9.figshare.5104873.v1
—
Reaction #490117
solid
Ausbeute 59.0%DOI: 10.6084/m9.figshare.5104873.v1
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