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197202

Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)nnc2C(N)=O)ccc1F
Reaction #1483557
tert-butyl (1S,2R)-2-(6-carbamoyl-5-(5-fluoro-6-methylpyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate
Ausbeute 46.1%DOI: 10.6084/m9.figshare.5104873.v1
[NH4+].[OH-]
Reaction #1483564
NH4OH
DOI: 10.6084/m9.figshare.5104873.v1
Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)nnc2C(N)=O)ccc1Cl
Reaction #1483567
tert-butyl (1S,2R)-2-(6-carbamoyl-5-(5-chloro-6-methylpyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate
Ausbeute 25.3%DOI: 10.6084/m9.figshare.5104873.v1
Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)cnc2C#N)ccc1Br
Reaction #1591936
tert-butyl (1S,2R)-2-(5-(5-bromo-6-methylpyridin-2-ylamino)-6-cyanopyridin-3-ylamino)cyclohexylcarbamate
DOI: 10.6084/m9.figshare.5104873.v1
Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)cnc2C(N)=O)ccc1O
Reaction #1591939
tert-butyl [(1S,2R)-2-({6-carbamoyl-5-[(5-hydroxy-6-methylpyridin-2-yl)amino]pyridin-3-yl}amino)cyclohexyl]carbamate
DOI: 10.6084/m9.figshare.5104873.v1
Cc1cc(O)cc(Nc2cc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)cnc2C(N)=O)n1
Reaction #1591940
tert-butyl [(1S,2R)-2-({6-carbamoyl-5-[(4-hydroxy-6-methylpyridin-2-yl)amino]pyridin-3-yl}amino)cyclohexyl]carbamate
DOI: 10.6084/m9.figshare.5104873.v1
Cc1cc(C)nc(Nc2cc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)cnc2C(N)=O)c1
Reaction #1592034
tert-butyl [(1S,2R)-2-({6-carbamoyl-5-[(4,6-dimethylpyridin-2-yl)amino]pyridin-3-yl}amino)cyclohexyl]carbamate
DOI: 10.6084/m9.figshare.5104873.v1
Cc1cc(C)nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)c1.Cl
Reaction #1592035
5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-[(4,6-dimethylpyridin-2-yl)amino]pyridine-2-carboxamide hydrochloric acid salt
DOI: 10.6084/m9.figshare.5104873.v1
Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)ccc1-c1cccc(C(O)C(F)F)c1
Reaction #1592045
5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-({5-[3-(2,2-difluoro-1-hydroxyethyl)phenyl]-6-methylpyridin-2-yl}amino)pyridine-2-carboxamide
DOI: 10.6084/m9.figshare.5104873.v1
Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)cnc2C#N)ccc1C#N
Reaction #1592050
tert-butyl [(1S,2R)-2-({6-cyano-5-[(5-cyano-6-methylpyridin-2-yl)amino]pyridin-3-yl}amino)cyclohexyl]carbamate
DOI: 10.6084/m9.figshare.5104873.v1
Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C#N)ccc1C#N
Reaction #1592051
5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-[(5-cyano-6-methylpyridin-2-yl)amino]pyridine-2-carbonitrile
DOI: 10.6084/m9.figshare.5104873.v1
Cc1cc(O)cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)n1.O=CO
Reaction #1592056
5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-[(4-hydroxy-6-methylpyridin-2-yl)amino]pyridine-2-carboxamide formic acid salt
DOI: 10.6084/m9.figshare.5104873.v1
Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)ccc1C(=O)O.O=C(O)C(F)(F)F
Reaction #1592065
6-[(5-{[(1R,2S)-2-aminocyclohexyl]amino}-2-carbamoylpyridin-3-yl)amino]-2-methylpyridine-3-carboxylic acid TFA salt
DOI: 10.6084/m9.figshare.5104873.v1
Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)cnc2C(N)=O)ccc1C(=O)N(C)C
Reaction #1592066
tert-butyl {(1S,2R)-2-[(6-carbamoyl-5-{[5-(dimethylcarbamoyl)-6-methylpyridin-2-yl]amino}pyridin-3-yl)amino]cyclohexyl}carbamate
DOI: 10.6084/m9.figshare.5104873.v1
Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)ccc1C(=O)N(C)C
Reaction #1592067
5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-{[5-(dimethylcarbamoyl)-6-methylpyridin-2-yl]amino}pyridine-2-carboxamide
DOI: 10.6084/m9.figshare.5104873.v1