Ethyl magnesium malonate

CCOC(=O)CC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)OCc1ccccc1
Reaction #302880
(2S)-2-benzyloxycarbonylamino-5-oxo-heptanedioic acid 1-benzyl ester 7-ethyl ester
Ausbeute 40.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2012_06
CCOC(=O)CC(=O)C[C@](O)(CCc1ccc(C(C)(C)C#N)c(F)c1)C1CCCC1
Reaction #946965
ethyl (5R)-7-[4-(1-cyano-1-methylethyl)-3-fluorophenyl]-5-cyclopentyl-5-hydroxy-3-oxoheptanoate
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2006_12
CCOC(=O)CC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)OCc1ccccc1
Reaction #1244282
(2S)-2-benzyloxycarbonylamino-5-oxo-heptanedioic acid 1-benzyl ester 7-ethyl ester
Ausbeute 40.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_10
CCOC(=O)CC(=O)c1cnc(SC)nc1OC
Reaction #1247617
desired compound
Ausbeute 52.4%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_10
CCOC(=O)CC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)OCc1ccccc1
Reaction #1516491
solid
Ausbeute 75.2%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2015_01
CCOC(=O)CC(=O)C[C@](O)(CCc1ccc(C(C)(C)C#N)c(F)c1)C1CCCC1
Reaction #1525549
ethyl (5R)-7-[4-(1-cyano-1-methylethyl)-3-fluorophenyl]-5-cyclopentyl-5-hydroxy-3-oxoheptanoate
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2009_11
CCOC(=O)CC(=O)C[C@](O)(CCc1ccc(C(C)(C)C#N)c(F)c1)C1CCCC1
Reaction #2474357
ethyl (5R)-7-[4-(1-cyano-1-methylethyl)-3-fluorophenyl]-5-cyclopentyl-5-hydroxy-3-oxoheptanoate
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2012_09