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Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(N[C@H]4CCC[C@@H](NC(=O)OC(C)(C)C)C4)n3)c3cc(Cl)cnc32)cc1
Reaction #162108
tert-butyl N-[(1R,3S)-3-[[2-[5-chloro-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-3-yl]-5-fluoro-pyrimidin-4-yl]amino]cyclohexyl]carbamate
Ausbeute 38.0%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(N[C@@H]4CCC[C@H](N)C4)n3)c3cc(Cl)cnc32)cc1
Reaction #162109
20c
Ausbeute 81.0%DOI: 10.6084/m9.figshare.5104873.v1
—
Reaction #162110
bis-hydrochloride
DOI: 10.6084/m9.figshare.5104873.v1
COCC(O)CN[C@@H]1CCC[C@H](Nc2nc(-c3c[nH]c4ncc(Cl)cc34)ncc2F)C1
Reaction #162115
desired product
DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(N[C@H]4CCC[C@@H](NC(=O)OC(C)(C)C)C4)n3)c3cc(Cl)cnc32)cc1
Reaction #614133
tert-butyl N-[(1R,3S)-3-[[2-[5-chloro-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-3-yl]-5-fluoro-pyrimidin-4-yl]amino]cyclohexyl]carbamate
Ausbeute 38.0%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(N[C@@H]4CCC[C@H](N)C4)n3)c3cc(Cl)cnc32)cc1
Reaction #614134
20c
Ausbeute 81.0%DOI: 10.6084/m9.figshare.5104873.v1
—
Reaction #614135
bis-hydrochloride
DOI: 10.6084/m9.figshare.5104873.v1
COCC(O)CN[C@@H]1CCC[C@H](Nc2nc(-c3c[nH]c4ncc(Cl)cc34)ncc2F)C1
Reaction #614140
1-[[(1R,3S)-3-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-pyrimidin-4-yl]amino]cyclohexyl]amino]-3-methoxy-propan-2-ol
DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(N[C@H]4CCC[C@@H](N5CCCC5=O)C4)n3)c3cc(Cl)cnc32)cc1
Reaction #614176
final product
DOI: 10.6084/m9.figshare.5104873.v1
O=C1CCCN1[C@@H]1CCC[C@H](Nc2nc(-c3c[nH]c4ncc(Cl)cc34)ncc2F)C1
Reaction #614177
HCl
DOI: 10.6084/m9.figshare.5104873.v1
O=c1[nH]c(=O)n([C@@H]2CCC[C@H](Nc3nc(-c4c[nH]c5ncc(Cl)cc45)ncc3F)C2)o1
Reaction #614220
desired product
DOI: 10.6084/m9.figshare.5104873.v1