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1137092

CS(=O)(=O)C(=C1CNC1)c1cc(F)cc(F)c1
Reaction #53474
3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
DOI: 10.6084/m9.figshare.5104873.v1
CC1(C)CCCN(Cc2ccc([C@H](c3ccc(Cl)cc3)N3CC(=C(c4cc(F)cc(F)c4)S(C)(=O)=O)C3)cc2)C1
Reaction #53475
1-{(R*)-(4-chlorophenyl)[4-(3,3-dimethylpiperidin-1-ylmethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
Ausbeute 69.5%DOI: 10.6084/m9.figshare.5104873.v1
CS(=O)(=O)C(=C1CN([C@@H](c2ccc(Cl)cc2)c2ccc(CN3CCSCC3)cc2)C1)c1cc(F)cc(F)c1
Reaction #53476
1-{(R*)-(4-chlorophenyl)[4-(thiomorpholin-4-ylmethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
Ausbeute 79.4%DOI: 10.6084/m9.figshare.5104873.v1
CCCN(CCC)C[C@@]1(c2ccccc2Cl)C=CC(CN2CC(=C(c3cc(F)cc(F)c3)S(C)(=O)=O)C2)=CC1
Reaction #53477
(R*)-(4-(chlorophenyl)[4-(di-n-propylaminomethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
DOI: 10.6084/m9.figshare.5104873.v1
CS(=O)(=O)C(=C1CN([C@@H](c2ccc(Cl)cc2)c2ccc(CN3CCCCC3)cc2)C1)c1cc(F)cc(F)c1
Reaction #53478
1-{(R*)-(4-chlorophenyl)[4-(piperidin-1-ylmethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
Ausbeute 63.9%DOI: 10.6084/m9.figshare.5104873.v1
CN1CCN(Cc2ccc([C@H](c3ccc(Cl)cc3)N3CC(=C(c4cc(F)cc(F)c4)S(C)(=O)=O)C3)cc2)CC1
Reaction #53479
1-{(R*)-(4-chlorophenyl)[4-(4-methylpiperazin-1-ylmethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
Ausbeute 44.4%DOI: 10.6084/m9.figshare.5104873.v1
CS(=O)(=O)C(=C1CN([C@@H](c2ccc(Cl)cc2)c2ccc(CN3CCNC(=O)C3)cc2)C1)c1cc(F)cc(F)c1
Reaction #53480
1-{(R*)-(4-chlorophenyl)[4-(piperazin-2-on-4-ylmethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
Ausbeute 39.1%DOI: 10.6084/m9.figshare.5104873.v1
CS(=O)(=O)C(=C1CN([C@@H](c2ccc(Cl)cc2)c2ccc(Cn3ccnc3)cc2)C1)c1cc(F)cc(F)c1
Reaction #53481
1-{(R*)-(4-chlorophenyl)[4-(imidazol-1-ylmethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
Ausbeute 15.3%DOI: 10.6084/m9.figshare.5104873.v1
CS(=O)(=O)C(=C1CN([C@@H](c2ccc(Cl)cc2)c2ccc(CCl)cc2)C1)c1cc(F)cc(F)c1
Reaction #53482
1-{(R*)-[4-(chloromethyl)phenyl]-(4-chlorophenyl)methyl}-3-{(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
DOI: 10.6084/m9.figshare.5104873.v1
CS(=O)(=O)C(=C1CN(C(c2ccc(Cl)cc2)c2ccc(CN3CCCCC3)cc2)C1)c1cc(F)cc(F)c1
Reaction #182016
DOI: 10.1039/C8SC04228D
CS(=O)(=O)C(=C1CN(C(c2ccc(Cl)cc2)c2ccc(Cn3ccnc3)cc2)C1)c1cc(F)cc(F)c1
Reaction #195152
DOI: 10.1039/C8SC04228D
CS(=O)(=O)C(=C1CN(C(c2ccc(Cl)cc2)c2ccc(CCl)cc2)C1)c1cc(F)cc(F)c1
Reaction #197048
DOI: 10.1039/C8SC04228D
CS(=O)(=O)C(=C1CNC1)c1cc(F)cc(F)c1
Reaction #1145984
3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
DOI: 10.6084/m9.figshare.5104873.v1
CC1(C)CCCN(Cc2ccc([C@H](c3ccc(Cl)cc3)N3CC(=C(c4cc(F)cc(F)c4)S(C)(=O)=O)C3)cc2)C1
Reaction #1145985
1-{(R*)-(4-chlorophenyl)[4-(3,3-dimethylpiperidin-1-ylmethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
Ausbeute 69.5%DOI: 10.6084/m9.figshare.5104873.v1
CS(=O)(=O)C(=C1CN([C@@H](c2ccc(Cl)cc2)c2ccc(CN3CCSCC3)cc2)C1)c1cc(F)cc(F)c1
Reaction #1145986
1-{(R*)-(4-chlorophenyl)[4-(thiomorpholin-4-ylmethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
Ausbeute 79.4%DOI: 10.6084/m9.figshare.5104873.v1
CCCN(CCC)C[C@@]1(c2ccccc2Cl)C=CC(CN2CC(=C(c3cc(F)cc(F)c3)S(C)(=O)=O)C2)=CC1
Reaction #1145987
(R*)-(4-(chlorophenyl)[4-(di-n-propylaminomethyl)phenyl]methyl}-3-[(3,5-difluorophenyl) (methylsulfonyl)methylene]azetidine
DOI: 10.6084/m9.figshare.5104873.v1
CS(=O)(=O)C(=C1CN([C@@H](c2ccc(Cl)cc2)c2ccc(CN3CCCCC3)cc2)C1)c1cc(F)cc(F)c1
Reaction #1145988
1-{(R*)-(4-chlorophenyl)[4-(piperidin-1-ylmethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
Ausbeute 63.9%DOI: 10.6084/m9.figshare.5104873.v1
CN1CCN(Cc2ccc([C@H](c3ccc(Cl)cc3)N3CC(=C(c4cc(F)cc(F)c4)S(C)(=O)=O)C3)cc2)CC1
Reaction #1145989
1-{(R*)-(4-chlorophenyl)[4-(4-methylpiperazin-1-ylmethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
Ausbeute 44.4%DOI: 10.6084/m9.figshare.5104873.v1
CS(=O)(=O)C(=C1CN([C@@H](c2ccc(Cl)cc2)c2ccc(CN3CCNC(=O)C3)cc2)C1)c1cc(F)cc(F)c1
Reaction #1145990
1-{(R*)-(4-chlorophenyl)[4-(piperazin-2-on-4-ylmethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
Ausbeute 39.1%DOI: 10.6084/m9.figshare.5104873.v1
CS(=O)(=O)C(=C1CN([C@@H](c2ccc(Cl)cc2)c2ccc(Cn3ccnc3)cc2)C1)c1cc(F)cc(F)c1
Reaction #1145991
1-{(R*)-(4-chlorophenyl)[4-(imidazol-1-ylmethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine
Ausbeute 15.3%DOI: 10.6084/m9.figshare.5104873.v1
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