تفاعل #999909

معادلة التفاعل

[(4-chloro-phenyl)oxy]ethylamine

ethyl [(phenyloxy-carbonyl)oxy]acetate

→

ethyl{[({2-[(4-chlorophenyl)oxy]ethyl}-amino)carbonyl]oxy}acetate

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىIt is evaporated to dryness
2. 2
   أخرىthe product is purified by chromatography on silica gel
3. 3
   غسيلeluting with a 30/70 mixture of ethyl acetate and cyclohexane
4. 4
   workup.ADDITIONThis gives 0.7 g of oily product, containing ˜10% of cyclized oxazolidine dione product

الإجراء التجريبي

A solution of 0.6 g (3.5 mmol) of [(4-chloro-phenyl)oxy]ethylamine (Chim. Ther. 1973, 8, 259-270) and 1.3 g (5.8 mmol) of ethyl [(phenyloxy-carbonyl)oxy]acetate, prepared in Step 1.1., in 30 ml of toluene is heated at 60° C. overnight. It is evaporated to dryness and the product is purified by chromatography on silica gel, eluting with a 30/70 mixture of ethyl acetate and cyclohexane. This gives 0.7 g of oily product, containing ˜10% of cyclized oxazolidine dione product, used as it is in the following step.

المصدر