تفاعل #9996

معادلة التفاعل

2-chloro-9-ethyl-6-(3-trifluoromethyl-phenyl-amino)-9H-purine

3-amino-1-propanol

→

9-Ethyl-2-(3-hydroxy-propyl-amino)-6-(3-trifluoromethyl-phenyl-amino)-9H-purine

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool
2. 2
   غسيلThe organic phase is washed with water
3. 3
   تجفيفdried over sodium sulfate
4. 4
   أخرىAfter removal of the solvent
5. 5
   أخرىthe residue is recrystallized from ethyl acetate and diethyl ether

الإجراء التجريبي

200 mg (0.58 mmol) of 2-chloro-9-ethyl-6-(3-trifluoromethyl-phenyl-amino)-9H-purine and 2 ml of 3-amino-1-propanol are stirred at 140° C. for 2 h and the mixture is allowed to cool and is diluted with 60 ml of ethyl acetate. The organic phase is washed with water and dried over sodium sulfate. After removal of the solvent, the residue is recrystallized from ethyl acetate and diethyl ether. 9-Ethyl-2-(3-hydroxy-propyl-amino)-6-(3-trifluoromethyl-phenyl-amino)-9H-purine is obtained; m.p. 136–137° C.; FAB-MS: (M+H)+=381; Rf=0.7 (ethyl acetate:methanol=9:1).

المصدر