تفاعل #9969

معادلة التفاعل

(±)-7-Amino-1,2,3,5,6,7,8,8a-octahydroindolizine

4-formylpyridine

magnesium sulfate

→

title compound

المردود 100.7%

(±)-7-(Pyridin-4-yl)methyleneamino-1,2,3,5,6,7,8,8a-octahydroindolizine

المردود 100.7%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   ترشيحAt the end of this time, the reaction mixture was filtered
2. 2
   أخرىto remove the catalyst
3. 3
   تركيزthe filtrate was concentrated by evaporation under reduced pressure

الإجراء التجريبي

(±)-7-Amino-1,2,3,5,6,7,8,8a-octahydroindolizine (4.91 g (35.0 mmol), prepared as described in 1)) was dissolved in toluene (95 ml). To the solution were added 4-formylpyridine (3.34 ml, 35.0 mmol) and anhydrous magnesium sulfate (3.75 g, 31.2 mmol), and the resulting mixture was stirred at 70° C. for 3 hours. At the end of this time, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated by evaporation under reduced pressure, to give the title compound (8.08 g) as a pale yellow oil (yield quantitative).

المصدر