تفاعل #992773

معادلة التفاعل

2,6-Difluoro-4-morpholin-4-yl-phenylamine

cyclopentylacetyl chloride

→

title compound

المردود 75.0%

2-Cyclopentyl-N-(2,6-difluoro-4-morpholin-4-yl-phenyl)-acetamide

المردود 75.0%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated in vacuo
2. 2
   أخرىpurified by flash chromatography

الإجراء التجريبي

2,6-Difluoro-4-morpholin-4-yl-phenylamine (0.20 g) and cyclopentylacetyl chloride (149 μL) were dissolved in acetonitrile (4 mL) and heated to 150° C. for 10 minutes in a sealed microwave process vial. The reaction mixture was concentrated in vacuo and purified by flash chromatography to furnish 228 mg (75%) of the title compound as a white solid.

المصدر