تفاعل #992766

معادلة التفاعل

2-Bromo-4-morpholin-4-yl-6-trifluoromethyl-phenylamine

4-fluorophenylacetyl chloride

Water

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title compound

المردود 9.0%

N-(2-Bromo-4-morpholin-4-yl-6-trifluoromethyl-phenyl)-2-(4-fluoro-phenyl)-acetamide

المردود 9.0%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe product was extracted with ethyl acetate (3×25 mL)
2. 2
   غسيلThe organic phases were washed with brine (50 mL)
3. 3
   تجفيفdried over magnesium sulfate
4. 4
   تركيزconcentrated in vacuo
5. 5
   أخرىThe crude product was purified by flash chromatography

الإجراء التجريبي

2-Bromo-4-morpholin-4-yl-6-trifluoromethyl-phenylamine (0.236 g) and 4-fluorophenylacetyl chloride (0.105 mL) were dissolved in acetonitrile (5 mL) and heated to 150° C. for 10 minutes in a sealed microwave process vial. Water (25 mL) was added and the product was extracted with ethyl acetate (3×25 mL). The organic phases were washed with brine (50 mL), dried over magnesium sulfate and concentrated in vacuo. The crude product was purified by flash chromatography to furnish 0.027 g (9%) of the title compound as an off-white solid. LC-MS (m/z) 462 (MH+); tR=2.84, (UV, ELSD) 96%, 100%. 1H NMR (500 MHz, DMSO-d6): 3.23 (m, 4H), 3.62 (s, 2H), 3.72 (m, 4H), 7.14 (dd, 2H), 7.19 (d, 1H), 7.35 (dd, 2H), 7.46 (d, 1H), 9.78 (s, 1H).

المصدر