تفاعل #992765

معادلة التفاعل

(3,4-difluoro-phenyl)-acetic acid

thionyl chloride

→

title compound

المردود 100.0%

(3,4-Difluoro-phenyl)-acetyl chloride

المردود 100.0%

المذيبات

1,2-dichloroethane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was refluxed for 16 hours under argon
2. 2
   تركيزThe crude mixture was concentrated in vacuo

الإجراء التجريبي

To (3,4-difluoro-phenyl)-acetic acid (2.0 g) dissolved in 1,2-dichloroethane (5 mL) was added thionyl chloride (5 mL) and the mixture was refluxed for 16 hours under argon. The crude mixture was concentrated in vacuo to furnish 2.2 g (100%) of the title compound as a yellow oil. 1H NMR (500 MHz, CDCl3): 4.10 (s, 2H), 7.00 (m, 1H), 7.11 (m, 1H), 7.17 (m, 1H).

المصدر