تفاعل #992764

معادلة التفاعل

N-(4-amino-2,6-diethyl-phenyl)-4-methyl-benzenesulfonamide

bis-(2-bromoethyl)ether

N,N-diisopropyl-ethylamine

N-methylpyrrolidine

→

title compound

المردود 91.0%

N-(2,6-Diethyl-4-morpholin-4-yl-phenyl)-4-methyl-benzenesulfonamide

المردود 91.0%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with brine (30 mL) and saturated aqueous potassium carbonate (30 mL)
2. 2
   تجفيفdried over sodium sulfate
3. 3
   تركيزThe organic phase was concentrated in vacuo

الإجراء التجريبي

A mixture of N-(4-amino-2,6-diethyl-phenyl)-4-methyl-benzenesulfonamide (70 mg), bis-(2-bromoethyl)ether (33 μL), N,N-diisopropyl-ethylamine (115 μL) and N-methylpyrrolidine (0.3 mL) was heated to 180° C. for 20 minutes in a sealed microwave process vial. The mixture was diluted with ethyl acetate (20 mL), washed with brine (30 mL) and saturated aqueous potassium carbonate (30 mL), and dried over sodium sulfate. The organic phase was concentrated in vacuo to furnish 78 mg (91%) of the title compound. LC-MS (m/z) 389 (MH+); tR=2.77, (UV, ELSD) 57%, 98%. The crude product was used without further purification.

المصدر