تفاعل #992763

معادلة التفاعل

sodium dithionite

N-(2,6-diethyl-4-nitro-phenyl)-4-methyl-benzenesulfonamide

potassium carbonate

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title compound

المردود 27.2%

N-(4-Amino-2,6-dimethyl-phenyl)-4-methyl-benzenesulfonamide

المردود 27.2%

المذيبات

water

water

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling
2. 2
   استخلاصextracted with ethyl acetate (2×10 mL)
3. 3
   تجفيفThe combined organic phases were dried over sodium sulfate
4. 4
   تركيزconcentrated in vacuo
5. 5
   أخرىpurified by flash chromatography

الإجراء التجريبي

A solution of sodium dithionite (772 mg) in water (6 mL) was added to a solution of N-(2,6-diethyl-4-nitro-phenyl)-4-methyl-benzenesulfonamide (309 mg) in tetrahydrofuran (6 mL) and the resulting mixture was stirred at 50° C. for 20 hours. After cooling, the water was saturated with potassium carbonate and extracted with ethyl acetate (2×10 mL). The combined organic phases were dried over sodium sulfate, concentrated in vacuo and purified by flash chromatography to furnish 70 mg (25%) of the title compound as a off-white solid. The product was used directly in the following reaction without spectral characterization.

المصدر