تفاعل #992742

معادلة التفاعل

8-bromo-7-chloro-2-methoxy-[1,5]naphthyridine

diethyl malonate

→

title compound

2-(3-chloro-6-methoxy-[1,5]naphthyridin-4-yl) -acrylic acid ethyl ester

ظروف التفاعل

الإجراء التجريبي

Starting from 8-bromo-7-chloro-2-methoxy-[1,5]naphthyridine (41.75 g, 152.6 mmol) and diethyl malonate (70.2 mL, 3 eq.), the title compound was obtained as a white solid (31.35 g, 107.2 mmol) using the procedures reported in WO 2007/071936 for the analogous methyl ester.

المصدر