تفاعل #992697

معادلة التفاعل

aniline

1-naphthoyl chloride

water

ammonium hydroxide

→

solid

المردود 82.0%

Naphthalene-1-carboxylic acid phenylamide

المردود 82.0%

المذيبات

acetonitrile

diethyl ether

ظروف التفاعل

المعالجة

1. 1
   أخرىTo the solution so formed
2. 2
   أخرى20 min
3. 3
   أخرىThe phases were separated
4. 4
   غسيلthe aqueous phase was washed with 100 ml of dichloromethane
5. 5
   أخرىThe organic fractions were collected
6. 6
   تجفيفdried with magnesium sulfate
7. 7
   ترشيحfiltered
8. 8
   أخرىthe solvent was then removed under reduced pressure

الإجراء التجريبي

4.77 g of 1-naphthoyl chloride (TCI America) was dissolved in 100 ml of anhydrous acetonitrile. To the solution so formed, 2.28 ml of aniline (Sigma-Aldrich) was added in a dropwise fashion over a period of c.a. 20 min. The reaction was then refluxed for 2 h at 82° C. 100 ml of distilled water and 5 ml of concentrated ammonium hydroxide were added along with 100 ml of diethyl ether in a separatory funnel. The phases were separated and the aqueous phase was washed with 100 ml of dichloromethane. The organic fractions were collected and dried with magnesium sulfate, filtered and the solvent was then removed under reduced pressure to yield a white solid 5.07 g (82%; 20.5 mmol).

المصدر