تفاعل #991902

معادلة التفاعل

sodium

ethyl α-hydroxyisobutyrate

urea

→

5,5-dimethylhydantoin

المردود 52.7%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONIn a 5-liter three neck distillation flask
2. 2
   درجة الحرارةThe mixture was heated
3. 3
   workup.DISTILLATIONAfter ethanol and methanol were distilled off from the reaction mixture
4. 4
   workup.ADDITION2 l of water was added
5. 5
   استخلاصextracted twice with ethyl acetate
6. 6
   تجفيفThe extract was dried with Glauber's salt
7. 7
   ترشيحfiltered
8. 8
   workup.DISTILLATIONThe solvent was distilled off from the
9. 9
   استخلاصextract

الإجراء التجريبي

In a 5-liter three neck distillation flask were placed 1.5 l of ethanol, 92 g of metallic sodium, 472 g of ethyl α-hydroxyisobutyrate (4 mole), and 240 g of urea (4 mole). The mixture was heated and stirred on hot oil bath at 100° C. for 18 hours. After ethanol and methanol were distilled off from the reaction mixture and then 2 l of water was added therefor, the mixture was made acid with aqueous hydrochloric acid solution and then extracted twice with ethyl acetate. The extract was dried with Glauber's salt, and then filtered. The solvent was distilled off from the extract to obtain 270 g of 5,5-dimethylhydantoin having a melting point of 75° C.

المصدر