تفاعل #991002

معادلة التفاعل

hydrogen bromide

(-)-α-amino-4-hydroxybenzeneacetic acid

hydrobromic acid

formaldehyde

→

(-)-α-Amino-3-(bromomethyl)-4-hydroxybenzeneacetic acid hydrobromide

ظروف التفاعل

المعالجة

1. 1
   أخرىto precipitate
2. 2
   workup.WAITis continued for 30 minutes
3. 3
   أخرىThe title compound is collected
4. 4
   غسيلwashed with ether and acetone

الإجراء التجريبي

To a solution of (-)-α-amino-4-hydroxybenzeneacetic acid (0.6 mole) in a minimum amount of concentrated hydrobromic acid at 35°-40° C. is added 50 ml of aqueous formaldehyde (35-37%) (0.6 mole). The addition of hydrogen bromide gas is begun. After 5-10 minutes, a solid begins to precipitate. Stirring is continued for 30 minutes. The title compound is collected and washed with ether and acetone.

المصدر