تفاعل #987436

معادلة التفاعل

NEt3

1-isopropyl-piperidin-4-ylamine dihydrochloride

5-(5-Chloro-thiophen-2-yl)-3-imidazol-1-ylmethyl-isoxazole

NEt3

trichloroacetyl chloride

→

title compound

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-imidazole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirring
2. 2
   workup.WAITwas continued for 2 h at RT
3. 3
   تركيزThe mixture was concentrated
4. 4
   أخرىthe residue was purified by preparative HPLC
5. 5
   workup.ADDITIONThe fractions containing the product
6. 6
   أخرىwere evaporated

الإجراء التجريبي

To a solution of 5-(5-Chloro-thiophen-2-yl)-3-imidazol-1-ylmethyl-isoxazole (85 mg) and NEt3 (89 μL) in DCM (3 mL) was added trichloroacetyl chloride (43 μL) dropwise at 0° C. The mixture was stirred for 5 min at 0° C. and for 30 min at RT. More NEt3 (133 μL) and 1-isopropyl-piperidin-4-ylamine dihydrochloride (88 mg) were added and stirring was continued for 2 h at RT. The mixture was concentrated and the residue was purified by preparative HPLC. The fractions containing the product were evaporated to provide 67 mg of the title compound as its trifluoroacetate salt. MS (ESI+): mi/e=434, chloro pattern.

المصدر