تفاعل #9859

معادلة التفاعل

water

ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate

methylamine

→

ethyl 4-methylamino-2-methylthiopyrimidine-5-carboxylate

المردود 97.0%

المذيبات

ethanol

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىTo a 0° C.
2. 2
   أخرىthe phases were separated
3. 3
   تجفيفThe organic phase was dried over magnesium sulfate
4. 4
   ترشيحfiltered
5. 5
   أخرىThe filtrate was evaporated under reduced pressure

الإجراء التجريبي

To a 0° C. solution of 20 g (86 mmol) of ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate (Aldrich Chemical Co., Milwaukee, Wis., USA) in 250 mL of dichloromethane was slowly added 35 mL (281 mmol) of a 33% solution of methylamine in ethanol. After stirring for 30 minutes, 150 mL of water was added and the phases were separated. The organic phase was dried over magnesium sulfate and filtered. The filtrate was evaporated under reduced pressure to give 19 g (97%) of ethyl 4-methylamino-2-methylthiopyrimidine-5-carboxylate as a white solid.

المصدر