تفاعل #985327
ord-f07cb4c8e2b444a2ad2eedeaf712b641
معادلة التفاعل
2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide
sodium trimethylsilanolate
→
title compound
6-Chloro-1-methylcarbamoylmethyl-1H-indole-3-carboxylic acid
المتفاعلات
الكواشف
لا شيء
المذيبات
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1تركيزthe mixture was concentrated in vacuo
- 2أخرىpurified by prep
الإجراء التجريبي
2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide was suspended in DCE and treated with (2.2 eq.) of sodium trimethylsilanolate. After shaking at room temperature for 20 min, the mixture was concentrated in vacuo and purified by prep. HPLC to give the title compound.