تفاعل #985301

معادلة التفاعل

Morpholine

potassium carbonate

propargyl bromide

→

colorless oil

المردود 70.0%

4-Prop-2-ynyl-morpholine

المردود 70.0%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled in ice under nitrogen
2. 2
   workup.STIRRINGStirring
3. 3
   درجة الحرارةwithout cooling
4. 4
   ترشيحThe white suspension was filtered through paper
5. 5
   غسيلthe solids were washed with MeOH (100 ml)
6. 6
   أخرىthe MeOH was carefully evaporated
7. 7
   ترشيحfiltered through paper
8. 8
   أخرىcarefully evaporated
9. 9
   workup.DISTILLATIONFinally the oil was distilled at 60° C./16 mbar

الإجراء التجريبي

Morpholine (100 ml, 1.148 mol) was dissolved in MeOH (1 L) and cooled in ice under nitrogen, then potassium carbonate (120 g, 0.63 mol) and propargyl bromide (124 mL, 1.148 mol) were added while stirring in ice. Stirring without cooling was continued for 4 h. The white suspension was filtered through paper and the solids were washed with MeOH (100 ml) and the MeOH was carefully evaporated. The white precipitate was suspended in DCM (400 ml), filtered through paper, and carefully evaporated. Finally the oil was distilled at 60° C./16 mbar. One obtained 100 g (70%) of a colorless oil.

المصدر