تفاعل #985291

معادلة التفاعل

potassium carbonate

decyl bromide

mercaptoethanol

→

2-(decylthio)ethanol

المردود 94.0%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   أخرىpartitioned between water and 80% hexane/ethyl acetate
2. 2
   غسيلThe organic phase was washed with 2N sodium hydroxide
3. 3
   تجفيفdried over magnesium sulfate
4. 4
   أخرىthe volatiles removed under vacuum

الإجراء التجريبي

Under nitrogen, to a suspension of potassium carbonate (27 g, 200 mmol) in acetone (100 ml) was added decyl bromide (10 ml, 50 mmol) and mercaptoethanol (4.4 ml, 63 mmol). The suspension was stirred at room temperature for 2 days, then partitioned between water and 80% hexane/ethyl acetate. The organic phase was washed with 2N sodium hydroxide, dried over magnesium sulfate, and the volatiles removed under vacuum to give 2-(decylthio)ethanol (10.2 g, 47 mmol) as a colorless liquid that was used without further purification.

المصدر