تفاعل #985276

معادلة التفاعل

p-Bromo-benzaldehyde

ammonium acetate

malonic acid

→

p-bromo-β-phenylalanine

المردود 63.0%

المذيبات

ethanol water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated
2. 2
   ترشيحfiltered
3. 3
   درجة الحرارةunder heating
4. 4
   أخرىdried under reduced pressure

الإجراء التجريبي

p-Bromo-benzaldehyde (10.0 g, 54 mmol) was mixed with 100 ml of ethanol/water (95/5), 8.3 g of ammonium acetate (108 mmol), and 11.2 g of malonic acid (108 mmol), heated under reflux at 80° C. with stirring for 17 hours, filtered under heating and dried under reduced pressure to give 8.3 g of p-bromo-β-phenylalanine crystals at a yield of 62.8%.

المصدر