تفاعل #985264

معادلة التفاعل

dimethyl-5-nitroisophthalate

ethanolamine

→

N,N′-bis(2-hydroxyethyl)-5-nitro-1,3-benzenedicarboxamide

المردود 67.3%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 48 hours
2. 2
   أخرىThe solvent was removed by evaporation under reduced pressure
3. 3
   أخرىThe crude product was purified by crystallization from EtOAC

الإجراء التجريبي

A solution containing dimethyl-5-nitroisophthalate (23.9 g, 100 mmol) and ethanolamine (13.4 g, 220 mmol) in methanol (300 mL) was refluxed for 48 hours. The solvent was removed by evaporation under reduced pressure. The crude product was purified by crystallization from EtOAC:MeOH 1 ml v/v) to afford 20.0 g of pure N,N′-bis(2-hydroxyethyl)-5-nitro-1,3-benzenedicarboxamide as white crystals. m.p.=151.3-151.4° C., uncorrected

المصدر