تفاعل #985261

معادلة التفاعل

4-nitrobenzoyl chloride

2-aminothiophenol

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product

المردود 73.2%

2-(4-Nitrophenyl)benzothiazole

المردود 73.2%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction was quenched with water (20 mL)
2. 2
   أخرىThe aqueous layer was separated
3. 3
   استخلاصextracted with ethyl acetate (3×10 ml)
4. 4
   أخرىThe combined organic layers were dried
5. 5
   أخرىevaporated
6. 6
   أخرىThe crude product was purified
7. 7
   أخرىwith flush column, (hexane:ethyl acetate=85:15)

الإجراء التجريبي

A solution of 4-nitrobenzoyl chloride (1.49 g, 8.0 mmol) in benzene anhydrous, 10 mL) was added dropwise to 2-aminothiophenol (1.0 g, 8.0 mmol in 10 ml of benzene) at room temperature. The reaction mixture was allowed to stir for 16 hr. The reaction was quenched with water (20 mL). The aqueous layer was separated and extracted with ethyl acetate (3×10 ml). The combined organic layers were dried and evaporated. The crude product was purified with flush column, (hexane:ethyl acetate=85:15) to give 1.5 g (73.2%) of product as light yellow solid.

المصدر