تفاعل #985244

معادلة التفاعل

sodium azide

p-toluenesulfonyl chloride

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title compound

المردود 80.3%

p-toluenesulfonylazide

المردود 80.3%

المذيبات

ethanol

H2O

ethanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added dropwise at 10-25° C.
2. 2
   أخرىfollowed by reaction at room temperature for 2.5 hours
3. 3
   تركيزThe reaction solution was concentrated at room temperature under reduced pressure
4. 4
   غسيلThe resulting oily residue was washed with H2O several times
5. 5
   تجفيفdried over anhydrous MgSO4
6. 6
   أخرىAfter removing the drying agent
7. 7
   ترشيحby filtration

الإجراء التجريبي

After dissolving sodium azide (22.5 g, 0.35 mole) in a small amount of H2O, the resulting solution was diluted with a 90% ethanol aqueous solution (130 ml). To this, an ethanol solution dissolving p-toluenesulfonyl chloride (60 g, 0.32 mole) was added dropwise at 10-25° C., followed by reaction at room temperature for 2.5 hours. The reaction solution was concentrated at room temperature under reduced pressure. The resulting oily residue was washed with H2O several times and dried over anhydrous MgSO4. After removing the drying agent by filtration, there was obtained 50.7 g of the title compound as a colorless oil.

المصدر