تفاعل #981529

معادلة التفاعل

pentafluorobenzyl alcohol

2-chloro-1-diethylamino-1,1,2-trifluoroethane

→

pentafluorobenzyl fluoride

المذيبات

methylene dichloride

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONat 0° C. the reaction mixture was poured into ice
2. 2
   أخرىthe organic layer was separated
3. 3
   غسيلwashed with IM aqueous sodium carbonate solution
4. 4
   تجفيفThe organic layer was dried over anhydrous sodium sulfate
5. 5
   أخرىthe solvent was removed by distillation
6. 6
   workup.DISTILLATIONthe product was distilled under reduced pressure

الإجراء التجريبي

A mixture of pentafluorobenzyl alcohol (3.0 g) and dry methylene dichloride (50 ml) was cooled to a temperature of 0° C. in an ice-bath and 2-chloro-1-diethylamino-1,1,2-trifluoroethane (4.3 g) was slowly added to the cooled, stirred mixture over a period of ten minutes. After standing for a period of 18 hr. at 0° C. the reaction mixture was poured into ice and the organic layer was separated and washed with IM aqueous sodium carbonate solution. The organic layer was dried over anhydrous sodium sulfate, the solvent was removed by distillation and the product was distilled under reduced pressure to give pentafluorobenzyl fluoride, b.p. 51° C. at 30 mm Hg.

المصدر