تفاعل #981391

معادلة التفاعل

benzenethiol

potassium carbonate

methyl 6,11-dihydro-11-chlorodibenz[b,e]oxepin-2-carboxylic acid

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title product

Methyl 6,11-Dihydro-11-phenylthiodibenz[b,e]oxepin-2-carboxylate

المذيبات

water

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstir for 15 minutes
2. 2
   استخلاصextract with ether
3. 3
   غسيلWash the
4. 4
   استخلاصextract with 5% aqueous potassium hydroxide and with saturated aqueous sodium chloride solution
5. 5
   تجفيفDry over anhydrous sodium sulfate
6. 6
   تركيزconcentrate to dryness

الإجراء التجريبي

Add 0.12 ml of benzenethiol to a 70° C. suspension of 0.5 gm of potassium carbonate in 5 ml of dimethylformamide. Stir under a nitrogen atmosphere for 10 minutes. Add 0.27 gm of methyl 6,11-dihydro-11-chlorodibenz[b,e]oxepin-2-carboxylic acid and stir for 15 minutes. Dilute with water and extract with ether. Wash the extract with 5% aqueous potassium hydroxide and with saturated aqueous sodium chloride solution. Dry over anhydrous sodium sulfate and concentrate to dryness to obtain the title product (Yield 0.226 gm).

المصدر