تفاعل #981390

معادلة التفاعل

ester

Methyl 6,11-Dihydro-11-methoxydibenz[b,e]oxepin-2-carboxylate

sodium hydroxide

→

title product

6,11-dihydro-11-methoxydibenz[b,e]oxepin-2-carboxylic Acid

المذيبات

water

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةreflux for 10 minutes
2. 2
   استخلاصextract with ether
3. 3
   استخلاصextract into ether
4. 4
   أخرىEvaporate to dryness
5. 5
   أخرىcrystallize from methanol

الإجراء التجريبي

Dissolve 695 mg of the ester of Step A in 15 ml of methanol. Add 10 ml of 20% aqueous sodium hydroxide and reflux for 10 minutes. Dilute with 200 ml of water and extract with ether. Acidify the aqueous fraction with concentrated hydrochloric acid and extract into ether. Evaporate to dryness and crystallize from methanol to obtain the title product (m.p. 185° C. dec.).

المصدر