تفاعل #981385

ord-f95130f624694dc18cad3d9e7606e10a

معادلة التفاعل

COC(=O)c1ccc2c(c1)C(S(C)(=O)=O)c1ccccc1CO2
ester
COC(=O)c1ccc2c(c1)C(S(C)(=O)=O)c1ccccc1CO2
Methyl 6,11-Dihydro-11-methylsulfonyldibenz[b,e]oxepin-2-carboxylate
[Na+].[OH-]
sodium hydroxide
Cl
hydrochloric acid
→
CS(=O)(=O)C1c2ccccc2COc2ccc(C(=O)O)cc21
title product
CS(=O)(=O)C1c2ccccc2COc2ccc(C(=O)O)cc21
6,11-Dihydro-11-methylsulfonyldibenz[b,e]oxepin-2-carboxylic Acid

المتفاعلات

COC(=O)c1ccc2c(c1)C(S(C)(=O)=O)c1ccccc1CO2
ester
COC(=O)c1ccc2c(c1)C(S(C)(=O)=O)c1ccccc1CO2
Methyl 6,11-Dihydro-11-methylsulfonyldibenz[b,e]oxepin-2-carboxylate
[Na+].[OH-]
sodium hydroxide
Cl
hydrochloric acid

الكواشف

لا شيء

المذيبات

O
water

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    درجة الحرارةReflux 1 gm
  2. 2
    أخرىSeparate the solids
  3. 3
    ترشيحby filtration

الإجراء التجريبي

Reflux 1 gm. of the ester of Step A and 40 cc. of 1 N aqueous sodium hydroxide for 15 minutes. Strip to dryness and dissolve the residue in water. Acidify with aqueous hydrochloric acid. Separate the solids by filtration to obtain the title product (m.p. 251° C. dec.).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US04282365uspto-grants-1981_08