تفاعل #981382

معادلة التفاعل

methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate

tetrahydrofuran

sodium hydroxide

→

title product

6,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylic Acid

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.DISSOLUTIONDissolve 900 mg
2. 2
   workup.ADDITIONAdd 20 cc
3. 3
   استخلاصextract with ether
4. 4
   استخلاصextract with ether
5. 5
   أخرىEvaporate the organic phase

الإجراء التجريبي

Dissolve 900 mg. of methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate in 20 cc. of tetrahydrofuran. Add 20 cc. 1 N aqueous sodium hydroxide. Stir at room temperature for 48 hours. Dilute with water and extract with ether. Acidify the aqueous fraction with hydrochloric acid and extract with ether. Evaporate the organic phase to obtain the title product (m.p. 275° C. dec.).

المصدر