تفاعل #978289

معادلة التفاعل

7-undecene

phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate

Phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate

4-hydroxybenzenesulfonamide

acetonitrile

→

title compound

المردود 75.6%

N-[({2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]-4-hydroxybenzenesulfonamide

المردود 75.6%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with 1 M hydrochloric acid and sat. NaHCO3 aq. The organic fraction
2. 2
   تجفيفwas dried over MgSO4
3. 3
   تركيزconcentrated under reduced pressure
4. 4
   أخرىThe residue was purified by TLC with dichloromethane/methanol (10:1)

الإجراء التجريبي

A mixture of phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22, 100 mg, 0.24 mmol), 4-hydroxybenzenesulfonamide (42 mg, 0.24 mmol), acetonitrile (3 mL) and 1,8-[5.4.0]-7-undecene (36 μL, 0.24 mmol) was stirred at room temperature for 16 h. The mixture was diluted with dichloromethane, and washed with 1 M hydrochloric acid and sat. NaHCO3 aq. The organic fraction was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by TLC with dichloromethane/methanol (10:1) to afford 89 mg (74%) of the title compound as white solids: 1H-NMR [CDCl3/CD3OD(4:1)] δ 7.73-7.68 (2H, m), 7.48-7.23 (9H, m), 6.88-6.83 (2H, m), 3.47 (2H, t, J=6.7 Hz), 2.84 (2H, t, J=6.7 Hz), 2.33 (3H, s), 2.26 (3H, s).

المصدر