تفاعل #978052

معادلة التفاعل

4,5-Diphenyloxazolone

4,5-diphenyloxazolone

triethylamine

phosphorous oxychloride

→

2-chloro-4,5-diphenyloxazole

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for 4.0 hours
2. 2
   تركيزThe mixture was concentrated in vacuo
3. 3
   workup.DISSOLUTIONdissolved in ether (250 mL)
4. 4
   غسيلwashed with 1N HCl, brine, and water
5. 5
   تجفيفdried over MgSO4
6. 6
   تركيزconcentrated to a light yellow oil which
7. 7
   أخرىwas used in the next step without further purification or characterization

الإجراء التجريبي

4,5-Diphenyloxazolone from Step 1 (30 g, 0.126 mol), triethylamine (12.8 g, 0.126 mol), and phosphorous oxychloride (96.6 g, 0.63 mol) were stirred at reflux for 4.0 hours. The mixture was concentrated in vacuo, dissolved in ether (250 mL), washed with 1N HCl, brine, and water, dried over MgSO4 and concentrated to a light yellow oil which was used in the next step without further purification or characterization.

المصدر