تفاعل #977136

معادلة التفاعل

2-Bromomethyl-4-nitro-1-pentafluoroethyl-benzene

N-Boc-piperazine

NaHCO3

→

compound

1-Boc-4-(5-nitro-2-pentafluoroethyl-benzyl)-piperazine

المذيبات

CH2Cl2

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with sat'd NH4Cl
2. 2
   تجفيفdried over MgSO4
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated
5. 5
   أخرىThe residue was purified by silica gel chromatography (hexane, CH2Cl2:hexane 2:8)

الإجراء التجريبي

2-Bromomethyl-4-nitro-1-pentafluoroethyl-benzene (2.5 g) was dissolved in CH2Cl2 and added to N-Boc-piperazine (2.5 g) and NaHCO3 (1 g) and stirred at RT overnight. The mixture was diluted with CH2Cl2 (100 ml), washed with sat'd NH4Cl, dried over MgSO4, filtered and concentrated. The residue was purified by silica gel chromatography (hexane, CH2Cl2:hexane 2:8) to give the compound as an yellow solid.

المصدر