تفاعل #975384

معادلة التفاعل

tert-butyl 4-cyanopiperazine-1-carboxylate

hydroxylamine

→

title compound

المردود 80.8%

tert-Butyl 4-[(hydroxyamino)(imino)methyl]piperazine-1-carboxylate

المردود 80.8%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated under vacuum
2. 2
   أخرىThe residue was triturated with hexane (100 mL)
3. 3
   ترشيحfiltered

الإجراء التجريبي

To a solution of tert-butyl 4-cyanopiperazine-1-carboxylate (15 g, 76 mmol) in EtOH (150 mL) was added hydroxylamine (50% aqueous solution, 6.2 mL, 92 mmol) and the reaction mixture was stirred at RT for 6 hours. The solvent was evaporated under vacuum. The residue was triturated with hexane (100 mL) and filtered to give 15 g (80%) of The title compound as a solid. TLC-CHCl3/MeOH (9/1): Rf=0.15.

المصدر