تفاعل #974977

معادلة التفاعل

(5-Chloro-2-methyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-ylidene)acetonitrile

ammonia methanol

→

title compound

المردود 100.0%

2-(5-chloro-2-methyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-ylidene)ethanamine

المردود 100.0%

المذيبات

methanol

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere added to the solution
2. 2
   ترشيحThe catalyst was filtered off through celite
3. 3
   تركيزthe filtrate was concentrated under reduced pressure

الإجراء التجريبي

(5-Chloro-2-methyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-ylidene)acetonitrile (116 mg, 2.87 mmol) was dissolved in a mixture of methanol (5 mL) and tetrahydrofuran (5 mL), Raney cobalt (1 g) and 8M ammonia/methanol solution (2 mL) were added to the solution, and the mixture was stirred under a hydrogen atmosphere at room temperature for 4 hr. The catalyst was filtered off through celite, and the filtrate was concentrated under reduced pressure to give the title compound (118 mg, yield 100%).

المصدر