تفاعل #974921

معادلة التفاعل

methyl 3-amino-6-bromo-2-methylbenzoate

sodium nitrite

→

title compound

المردود 86.0%

methyl 5-bromo-1H-indazole-4-carboxylate

المردود 86.0%

المذيبات

acetic acid

water

ظروف التفاعل

المعالجة

1. 1
   أخرىthe organic solvent was evaporated under reduced pressure
2. 2
   workup.ADDITIONThe residual aqueous solution was diluted with saturated aqueous sodium hydrogen carbonate solution
3. 3
   استخلاصthe mixture was extracted with ethyl acetate
4. 4
   غسيلThe extract was washed with saturated brine
5. 5
   تجفيفdried over anhydrous sodium sulfate
6. 6
   أخرىThe solvent was evaporated under reduced pressure
7. 7
   أخرىthe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane=10/90→30/70)

الإجراء التجريبي

To a solution of methyl 3-amino-6-bromo-2-methylbenzoate (5.44 g, 22.3 mmol) in acetic acid (110 mL) was added a solution of sodium nitrite (1.69 g, 24.5 mmol) in water (11 mL) at room temperature and, after stirring for 20 hr, the organic solvent was evaporated under reduced pressure. The residual aqueous solution was diluted with saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane=10/90→30/70) to give the title compound (4.86 g, yield 86%).

المصدر