تفاعل #974718

معادلة التفاعل

2-Bromomethyl-4-nitro-1-pentafluoroethyl-benzene

N-Boc-piperazine

NaHCO3

→

compound

1-Boc-4-(5-nitro-2-pentafluoroethyl-benzyl)-piperazine

المذيبات

CH2Cl2

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with sat'd NH4Cl
2. 2
   أخرىdried over MgSO41
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated
5. 5
   أخرىThe residue was purified by silica gel chromatography (hexane, CH2Cl2:hexane 2:8)

الإجراء التجريبي

2-Bromomethyl-4-nitro-1-pentafluoroethyl-benzene (2.5 g) was dissolved in CH2Cl2 and added to N-Boc-piperazine (2.5 g) and NaHCO3 (1 g) and stirred at RT overnight. The mixture was diluted with CH2Cl2 (100 ml), washed with sat'd NH4Cl, dried over MgSO41 filtered and concentrated. The residue was purified by silica gel chromatography (hexane, CH2Cl2:hexane 2:8) to give the compound as a yellow solid.

المصدر