تفاعل #973

معادلة التفاعل

N-(5-fluoro-2-nitrophenyl)-S-methyl-L-cysteine

N-(5-Fluoro-2-nitrophenyl)-S-methyl-L-cysteine

sodium methoxide

→

N-(5-Methoxy-2-nitrophenyl)-S-methyl-L-cysteine

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwhile cooling by means of an ice bath
2. 2
   درجة الحرارةThe mixture is then heated
3. 3
   درجة الحرارةto reflux for 2 hours
4. 4
   workup.STIRRINGwhile stirring

الإجراء التجريبي

27 g of N-(5-fluoro-2-nitrophenyl)-S-methyl-L-cysteine (0.1 mol) from Example 1 are dissolved in 150 ml of absolute methanol in a four-necked flask, and 14.4 g of 95% sodium methoxide (0.25 mmol) are added in portions, within the space of 20 minutes and under argon, to this solution while stirring well and while cooling by means of an ice bath. The mixture is then heated to reflux for 2 hours while stirring. TLC monitoring then indicates that the reaction is complete.

المصدر