تفاعل #969876

معادلة التفاعل

piperidine

Fmoc-Val-Pro doxorubicin

→

compound G

المردود 50.0%

H-Val-Pro doxorubicin

المردود 50.0%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىform red to purple)
2. 2
   أخرىThen, the reaction mixture was evaporated to dryness under reduced pressure
3. 3
   أخرىthe residue thus obtained
4. 4
   أخرىwas purified by reverse phase chromatography with water/acetonitrile (70:1)

الإجراء التجريبي

A solution of piperidine in dimethylformamide 50% (1.92 mL) was added to Fmoc-Val-Pro-doxorubicin (F) (29.7 mg, 0.03 mmol) and the reaction mixture was stirred at room temperature for 1 minute (the reaction colour changes form red to purple). Then, the reaction mixture was evaporated to dryness under reduced pressure and the residue thus obtained was purified by reverse phase chromatography with water/acetonitrile (70:1) to give the deprotected compound G (50% yield)

المصدر