تفاعل #9676

معادلة التفاعل

1,2-diamino-4,5-difluorobenzene

cyanogen bromide

sodium bicarbonate

→

5,6-difluoro-1H-benzimidazol-2-amine

المردود 98.8%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   تركيزwas then concentrated in vacuo
2. 2
   درجة الحرارةheated
3. 3
   درجة الحرارةat reflux for 15 minutes
4. 4
   ترشيحThe hot suspension was filtered
5. 5
   غسيلrinsing with hot ethanol
6. 6
   تركيزthe filtrate was concentrated in vacuo

الإجراء التجريبي

The procedure used was similar to that reported in J. Med. Chem. 40:811–818, 1997. A solution of 1,2-diamino-4,5-difluorobenzene (500 mg, 3.47 mmol) in water (5 mL) was cooled to 0° C. and then treated with a solution of cyanogen bromide (0.83 mL, 4.16 mmol, 5 M in acetonitrile) and solid sodium bicarbonate (583 mg, 6.94 mmol). The solution was stirred at rt overnight and was then concentrated in vacuo. The dark residue was suspended in ethanol and heated at reflux for 15 minutes. The hot suspension was filtered, rinsing with hot ethanol, and the filtrate was concentrated in vacuo to afford 5,6-difluoro-1H-benzimidazol-2-amine (580 mg, 59%), which was used in the next step without further purification. LC-MS m/z 170.2 (MH+), ret. time 0.85 min; 1H NMR (300 MHz, DMSO-d6) δ 6.30 (br s, 2H), 7.06 (dd, 2H), 10.79 (br s, 1H).

المصدر