تفاعل #9669

معادلة التفاعل

Sulfuryl chloride

5-fluoro-1,3-benzothiazole-2-thiol

→

2-Chloro-5-fluoro-1,3-benzothiazole

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated at 60° C. for 30 minutes
2. 2
   درجة الحرارةThe resulting solution was cooled to rt
3. 3
   workup.ADDITIONpoured onto ice
4. 4
   ترشيحThe title compound was collected by filtration
5. 5
   غسيلwashed with water
6. 6
   أخرىdried under vacuum
7. 7
   أخرىThe solid obtained
8. 8
   أخرىwas used without further purification

الإجراء التجريبي

Sulfuryl chloride (50 μL, 0.65 mmol) was added neat to 5-fluoro-1,3-benzothiazole-2-thiol (100 mg, 0.54 mmol). The mixture was stirred at ambient temperature for 1 h, then heated at 60° C. for 30 minutes. The resulting solution was cooled to rt, and poured onto ice. The title compound was collected by filtration, washed with water, and dried under vacuum. The solid obtained was used without further purification; LC-MS m/z 188.1 (MH+), ret. time 3.27 min.

المصدر