تفاعل #966162

معادلة التفاعل

indole-6-carboxaldehyde

potassium carbonate

2,6-dimethylbenzyl chloride

→

titled compound

المردود 89.3%

1-(2,6-dimethylbenzyl)-1H-indole-6-carbaldehyde

المردود 89.3%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىirradiation at 160° C. for 30 minutes
2. 2
   أخرىThe reaction mixture was quenched with water
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   تجفيفThe obtained organic layer was dried over anhydrous sodium sulfate
5. 5
   ترشيحfiltered
6. 6
   تركيزthe filtrate was concentrated under reduced pressure
7. 7
   أخرىThe obtained residue was purified by silica gel column chromatography

الإجراء التجريبي

To a solution of indole-6-carboxaldehyde (457 mg) in N,N-dimethylformamide (5 mL) were added potassium carbonate (936 mg) and 2,6-dimethylbenzyl chloride (752 mg) at room temperature, and then the reaction mixture was subjected to microwave irradiation at 160° C. for 30 minutes. The reaction mixture was quenched with water, and extracted with ethyl acetate. The obtained organic layer was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give the titled compound (740 mg) as a yellow solid.

المصدر