تفاعل #966160

معادلة التفاعل

5-benzoimidazole carboxylic acid

potassium carbonate

2,6-dimethylbenzyl chloride

→

titled compound

المردود 40.7%

2,6-dimethylbenzyl 1-(2,6-dimethylbenzyl)-1H-benzimidazole-6-carboxylate

المردود 40.7%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was quenched with water
2. 2
   استخلاصextracted with chloroform
3. 3
   تجفيفThe obtained organic layer was dried over anhydrous sodium sulfate
4. 4
   ترشيحfiltered
5. 5
   تركيزthe filtrate was concentrated under reduced pressure
6. 6
   أخرىThe obtained residue was purified by silica gel column chromatography

الإجراء التجريبي

To a solution of 5-benzoimidazole carboxylic acid (1.1 g) in N,N-dimethylformamide (15 mL) were added potassium carbonate (2.7 g) and 2,6-dimethylbenzyl chloride (2.3 g) at room temperature, and then the reaction mixture was stirred at room temperature for 2 days. The reaction mixture was quenched with water, and extracted with chloroform. The obtained organic layer was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give the titled compound (1.1 g) as a white solid.

المصدر