تفاعل #966

معادلة التفاعل

3-(N-tert-butyloxycarbonylaminomethyl)-1-benzhydryl azetidine

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title compound

المردود 67.1%

3-(N-tert-butyloxycarbonylaminomethyl) azetidine

المردود 67.1%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe catalyst was filtered off
2. 2
   أخرىthe solvent evaporated
3. 3
   أخرىThe crude product was purified by flash chromatography

الإجراء التجريبي

3.4 g (9.6 mmol) of 3-(N-tert-butyloxycarbonylaminomethyl)-1-benzhydryl azetidine was dissolved in 170 mL MeOH and hydrogenated over 0.30 g Pd(OH)2 at 5 MPa over night. The catalyst was filtered off and the solvent evaporated. The crude product was purified by flash chromatography using MeOH/CH2Cl2, 1/9, followed by MeOH (saturated with NH3 (g))/CH2Cl2, 1/9, as eluent to yield 1.2 g (67%) of the title compound.

المصدر