تفاعل #9645

معادلة التفاعل

bromobenzene

EtOAc

AlCl3

SOCl2

DMF

→

desired product

المردود 95.0%

(±)-cis-2-(4-Bromo-benzoyl)-cyclopentanecarboxylic acid methyl ester

المردود 95.0%

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed by rotary evaporation at <40° C.
2. 2
   أخرىthe residue was dried in vacuo for 1 h
3. 3
   workup.STIRRINGAfter the mixture was stirred for 10 minutes
4. 4
   أخرىthe aqueous (top) layer was separated
5. 5
   استخلاصextracted with 500 mL EtOAc
6. 6
   غسيلThe combined organic layers were washed with water (2×1 L) and saturated NaHCO3 solution (200 mL)
7. 7
   تجفيفdried over Na2SO4
8. 8
   أخرىRemoval of solvent
9. 9
   أخرىdrying in vacuo

الإجراء التجريبي

A solution of the monomethyl ester (92.0 g, 534.3 mmol), SOCl2 (116.3 mL, 1.60 mol), and DMF (1 mL) in 850 mL CH2Cl2 was stirred at rt overnight under N2. NMR analysis showed little starting material remaining. The solvent was removed by rotary evaporation at <40° C., and the residue was dried in vacuo for 1 h. This dried residue was dissolved in bromobenzene (337.6 mL, 3.2 mol), and AlCl3 (142.5 g, 1.07 mol) was then added portionwise at <5° C. The reaction mixture turned dark brown, and was stirred at <5° C. for 4 h under N2. NMR analysis then showed little starting material remaining. The reaction mixture was then slowly poured into 2 L ice-water, and then 1 L EtOAc was added. After the mixture was stirred for 10 minutes, the aqueous (top) layer was separated, and extracted with 500 mL EtOAc. The combined organic layers were washed with water (2×1 L) and saturated NaHCO3 solution (200 mL), and dried over Na2SO4. Removal of solvent and drying in vacuo provided 175.0 g (>95%) of the desired product. 1H NMR (CDCl3) δ 7.80 (d, 2H), 7.60 (d, 2H), 4.07 (m, 1H), 3.53 (s, 3H), 3.07 (m, 1H), 2.20 (m, 1H), 2.00 (m, 4H), 1.70 (m, 1H).

المصدر