تفاعل #964107

معادلة التفاعل

6-Chloro-4-(3-methoxy-phenoxy)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

2-aminopyridine-5-boronic acid pinacol ester

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125

5-(4-(3-methoxyphenoxy)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)pyridin-2-amine

ظروف التفاعل

المعالجة

1. 1
   أخرىThe product was purified by reverse phase HPLC

الإجراء التجريبي

6-Chloro-4-(3-methoxy-phenoxy)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine (80 mg) was coupled to 2-aminopyridine-5-boronic acid pinacol ester via General Procedure A. The product was purified by reverse phase HPLC to yield 47.3 mg of 125. MS (Q1) 349.2 (M)+

المصدر