تفاعل #962157

معادلة التفاعل

6-(3-methylpiperazin-1-yl)nicotinonitrile

3-(5-(2,2,2-trifluoroacetyl)thiophen-2-yl)benzoic acid

→

6-(3-Methyl-4-(3-(5-(2,2,2-trifluoroacetyl)thiophen-2-yl)benzoyl)piperazin-1-yl)nicotinonitrile

المردود 39.0%

المذيبات

HCOOH

ظروف التفاعل

الإجراء التجريبي

This compound was synthesized from 6-(3-methylpiperazin-1-yl)nicotinonitrile and 3-(5-(2,2,2-trifluoroacetyl)thiophen-2-yl)benzoic acid as described for example 37 step 3 (95 mg, yield 39%). 1H NMR (400 MHz, MeOD) δ 8.42 (d, J=1.9 Hz, 1H), 7.97-7.96 (m, 1H), 7.80-7.77 (dt, J=7.8 Hz, 1.4 Hz, 1H), 7.75-7.74 (t, J=1.5 Hz, 1H), 7.68-7.65 (dd, J=9.1 Hz, 2.4 Hz, 1H), 7.58-7.54 (t, J=7.6 Hz, 1H), 7.48-7.45 (m, 2H), 6.64-6.62 (d, J=9.1 Hz, 1H), 4.40-4.23 (m, 4H), 3.42-3.37 (m, 2H), 3.16-3.09 (m, 1H), 1.33-1.31 (m, 3H). MS (ESI) m/z: Calculated for C24H19F3N4O2S: 484.12. found: 529.7 (M+HCOOH)−

المصدر