تفاعل #962

معادلة التفاعل

(3RS)-1-benzyl-3-chloromethyl pyrrolidine

sodium cyanide

Water

→

product

المردود 92.0%

(3RS)-1-benzyl-3-cyanomethyl pyrrolidine

المردود 92.0%

المذيبات

dimethyl sulfoxide

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe mixture was extracted three times with ethyl acetate
2. 2
   غسيلThe combined organic layer was washed with brine
3. 3
   تجفيفdried (Na2SO4)
4. 4
   ترشيحfiltered
5. 5
   أخرىevaporated

الإجراء التجريبي

16.8 g (0.08 mole) (3RS)-1-benzyl-3-chloromethyl pyrrolidine and 5.88 g (0.12 mole) of sodium cyanide was dissolved in 250 ml dimethyl sulfoxide. The mixture was stirred at 60° C. for two days and at room temperature for one week. Water was added and the mixture was extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried (Na2SO4), filtered and evaporated to yield 14.7 g (92%) of the product.

المصدر