تفاعل #96052

معادلة التفاعل

4-[4-chloro-3-(1-methyl-4-piperazinylsulfonyl)-phenyl]-3-methyl-2-phenyliminothiazolidin-4-ol

→

4-[4-Chloro-3-(1-methyl-4-piperazinylsulfonyl)-phenyl]-3-methyl-2-phenylimino-4-thiazoline

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   أخرىObtained by a procedure analogous to
2. 2
   workup.DISTILLATIONsubsequently distilling off the solvent
3. 3
   workup.ADDITIONWater is added to the residue
4. 4
   ترشيحThe crystals are filtered off
5. 5
   أخرىrecrystallized from isopropanol

الإجراء التجريبي

Obtained by a procedure analogous to that indicated in Example 2(b), from 4-[4-chloro-3-(1-methyl-4-piperazinylsulfonyl)-phenyl]-3-methyl-2-phenyliminothiazolidin-4-ol, by boiling with glacial acetic acid and subsequently distilling off the solvent. Water is added to the residue and the pH is adjusted to 13 with 2 N NaOH. The crystals are filtered off and recrystallized from isopropanol. Melting point 156°-158° C.

المصدر